The Science
A minimally invasive alternative to surgical lifting.
For medical professionals: the mechanism, the evidence and the safety profile behind Jamber's spring-type PDO scaffold, engineered by Neo Dr. Inc. (South Korea).
Jamber is a next-generation PDO thread system engineered around a spring-type scaffold. Unlike conventional mono- or cog-thread architectures, the coiled structure creates a three-dimensional matrix inside the dermal layer — the pre-cursor of a new collagen tube.
After placement, polydioxanone triggers a controlled foreign-body response. Fibroblasts are recruited via TGF-β1 signalling within two weeks. Type I collagen production climbs sharply around week eight, peaks at week twelve, and continues through to week forty-eight.
By month six to eight, the PDO has fully hydrolysed to water and carbon dioxide. What remains is the patient's own collagen — a three-dimensional, elastino-fibrillar network that continues to support skin structure for years.
- Material
- 100% PDO
- Absorption
- 6–8 months
- Collagen peak
- Week 12
- Structural support
- Up to 5 years
Bidirectional Collagen
Collagen forms inside the coil. And around it.
Standard PDO threads stimulate collagen only on the outside of the fibre. The Jamber scaffold produces collagen both inside and outside the coil — forming a collagen tube that delivers lifting and biostimulatory effect long after the thread itself has been fully absorbed.
Standard PDO
Collagen around the fibre only. Linear. No internal volume.
Jamber scaffold
Collagen inside and outside the spring. A true 3D matrix.
After absorption
Structural support continues for 9–12+ months — and beyond.
Timeline
From placement to five-year support.
Week 0
Placement. Immediate volume and lift via spring scaffold.
Week 2
Fibroblast recruitment begins via TGF-β1 signalling.
Week 8
Type I α1 collagen production rises sharply.
Week 12
Peak collagen deposition — biostimulation maximal.
Month 6–8
PDO fully hydrolyses to water and CO₂. The collagen tube remains.
Month 9–12+
Continuous improvement. Structural support consolidates.
Up to 5 years
Long-term structural support from the regenerated collagen tube.
Collagen scaffold remains
Migration · Tyndall · Occlusion
No migration. No Tyndall. No vascular occlusion.
Filler-only treatments migrate from the injection site, refract light under thin skin, and risk vascular compromise in high-risk anatomies. Jamber's scaffold eliminates all three by design — and when used with filler, holds the product exactly where it was placed.
Permanent Particles
100% absorbed. No permanent particles.
PLLA microspheres can persist for years; CaHA particles can remain indefinitely. Both are contraindicated near the eye. Jamber hydrolyses to water and CO₂ in 6–8 months, leaving only the patient's own regenerated collagen.
Downtime & Commitment
Reversible during absorption. No downtime.
The scaffold supports without committing the patient to surgical recovery. The PDO absorption window provides a built-in reversibility period that surgical refinement cannot offer.
Safety
Side-effect profile and management.
Jamber's side-effect profile is minimal. Most reactions are transient and self-resolving.
Common
Mild swelling
Self-resolves within 24–72 hours. Standard post-procedural care.
Rare
Thread extrusion
Gently withdraw the exposed end — the spring releases. No surgical intervention.
Rare
Placement correction
Open a small entry point with a needle and carefully extract the thread.